Winner of 2015 FAOBMB Young Scientist Award (Male): Dr Victor Anggono (Australia)
Dr. Victor Anggono
Queensland Brain Institute, The University of Queensland, Brisbane, Australia
Victor Anggono received his PhD in 2007 from the University of Sydney, working under the guidance of Professor Phil Robinson. Here his research revealed the essential role of dynamin phosphorylation in the synaptic vesicle endocytosis that is required to maintain synaptic transmission. This seminal work was published in Nature Neuroscience. For his work, Victor was awarded the Peter Bancroft Prize from the University of Sydney and the Australian Society for Biochemistry and Molecular Biology (ASBMB) Fellowship.
Subsequently, Victor received two prestigious fellowships from the International Human Frontiers Science Program and the Australian National Health and Medical Research Council to pursue his postdoctoral training at the Johns Hopkins University in Baltimore, USA, under the mentorship of Professor Richard Huganir. His research focussed on the molecular mechanisms that regulate AMPA receptor trafficking and synaptic plasticity, a cellular correlate of learning and memory. These studies, which were published in top journals, including Neuron, PNAS, and Journal of Neuroscience, revealed a role for the AMPA receptor-interacting protein PICK1 in homeostatic synaptic scaling and identified the interaction between PICK1 and PACSIN, as well as KIBRA, in controlling AMPA receptor trafficking and synaptic plasticity.
In 2011, Victor received the Boomerang Award from ASBMB, and in 2012 he returned to Australia and joined the Queensland Brain Institute at the University of Queensland, where he is currently a Group Leader and a member of the Clem Jones Centre for Ageing Dementia Research. A recent study from his laboratory, published in Cell Reports, revealed a role of protein ubiquitination in regulating AMPA receptor intracellular trafficking and lysosomal targeting for degradation. His laboratory is currently studying the role of AMPA receptor ubiquitination in synaptic plasticity, learning and memory, as well as its implication in the pathogenesis of Alzheimer’s disease.